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tebu-bio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Cell Biology and Signalling, Supplying Discovery Tools

Physioxia or Hypoxia: what it's all about

13/01/2015 by Frédéric Dubor, PhD No Comments

Cell culture under oxygen controlled conditions: an improvement towards more predictive results

Oxygen concentration in tissues is a key factor for cell and organ survival. In normal conditions, partial oxygen pressure (pO2) results in the balance between oxygen delivery and its consumption. Oxygen is transported, in mammals, by circulating red blood cells. Partial oxygen pressure in tissues varies widely, depending on their respective metabolic requirements and their functional status. In normal physiological conditions,  partial oxygen pressure is called physioxia. Any alteration of tissue environment leading to a decrease in partial oxygen pressure is called hypoxia. Hypoxic conditions have been observed in many different pathological situations like tumor development, obesity or transcient ischemia.

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Cell Biology and Signalling, Drug Discovery

Fluorescent ShK toxin for Kv1.3 ion channels

18/12/2014 by Ali El Baya, PhD No Comments

Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.

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Cell Biology and Signalling, Cell Sourcing - Cell Culture Technologies, Supplying Discovery Tools

3 Reasons to use fresh TLR9 agonists

12/12/2014 by Mark Livingstone No Comments

As part of the innate immune response, Toll-like receptor 9 recognizes unmethylated CpG nucleotide sequences, which are very common in viruses and prokaryotes and more rare in vetebrates. Scientists routinely use synthetic oligonucleotides as TLR9 agonists for a variety of applications requiring activation of an innate immune response via TLR9. These relatively simple oligonucleotides are easy to produce, and as a result some companies have extensive catalog offers.

TLR9 structure in complex with CpG ODN. Source: Zhou et al. doi:10.1186/1742-4682-10-18.

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Cell Biology and Signalling, Supplying Discovery Tools

Validated antibodies for Ectodermal Stem Cell Lineage

04/12/2014 by Philippe Fixe, PhD No Comments

Self-renewal and differentiation capacities into multiple cell-types are 2 main characteristics of Stem Cells. Contrarily to Embryonic Stem Cells, Adult Stem Cells (ASC) are already committed to a differentiated lineage. Nevertheless, ASC still retain capacities of generating various cell types within their restricted lineage. It’s thus crucial to be able to access high quality and reliable research tools when tracking cell differentiation. Here, we’ll review the most popular reagents used to characterize the ectodermal lineage.

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