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    ADME-Tox
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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Biomarkers

5 key criteria for selecting the most appropriate ELISA kit to detect Human Cardiotrophin-1

18/03/2014 by Philippe Fixe, PhD No Comments
Multipette and 96-well plate

Cardiotrophin-1 Factor

Cardiotrophin-1 (CT-1) is a cardiac hypertrophic factor with cardiac myocyte protective properties. CT-1 belongs to the interleukin-6 cytokine family and acts through LIF receptor ß/glycoprotein 130 (gp130)-coupled signaling pathways.

CT-1 intracellular signaling pathways enlist kinases (ERK, MAP, JAK) but also STAT and PI3-kinase/Akt systems.

Cardiac CT-1 expression is increased by hypoxia, where it protects cardiac myocytes from ischemic injury and apoptosis.

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Biomarkers, Cell Biology and Signalling

2 cost-effective antibody options for Hypoxia pathway analysis

12/03/2014 by Philippe Fixe, PhD No Comments
HIF1 alpha GTX127309 (IFA)

Low oxygen tension, or Hypoxia, regulates numerous cellular and tissular functions. In cancer research, hypoxia is a key regulator of tumor development, aggressiveness and therapy resistance by acting on malignant cells and their microenvironment. Hypoxia is also involved in age-related diseases and acts through intracellular and intercellular cascade of events (exosomes, paracrine loops, angiogenesis…) (1-2).

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