High density antibody arrays represent powerful technologies which have opened a new era in functional proteomics. However, when faced with a large magnitude of array data, you must apply comprehensive statistical and data mining analysis to discover potential biomarker panels and meaningful patterns. Biostatistical analysis can also help to evaluate the quality of protein expression data by detecting and extracting errors and confidence level. As one can get easily lost at this game, this post illustrates a selection of packages available, taking the example of High density antibody array services performed by tebu-bio laboratories in Europe, in collaboration with their partner RayBiotech. I doubt you will want to do it your self when you have realized what can be done for you, and at very affordable pricing!

Recombinant protein production and protein purification raises the tricky question of host cell proteins (HCPs). To monitor the purification level of your protein of interest, the HCPs must be quantified. Of course, the quality and the optimisation of purification depends upon it. Here, we’ll take a look at an alternative to the gold standard, offering a way to detect more HCPs present in the production. So, are you ready for higher grade detection?

In a previous post, I introduced Sekisui Xenotech’s Research Biobank, which is based on rejections from liver transplantation as opposed to post-mortem tissues, thus offering a guarantee for better tissue preservation and larger quantities versus biopsies. As donor demographics are known (BMI, diabetes, alcohol use…) , these tissues are very useful resources for advanced research on liver related diseases. The data summarized in this article, are an interesting illustration of results obtained based on these tissues. If you’d like to download the full content, I have included the link at the end of this post.

In a previous post, I introduced the G-Series Mouse antibody arrays to profile up to 200 mouse proteins using a combination of 5 antibody arrays on glass slide. This new Mouse L2 L-Series (label based antibody array) goes one step further in the number of targets to profile – 500 on one single array – allowing you to work with smaller sample volume. Read more about the technology and its advantages in this post, whether you’re considering using it in your lab, or outsourcing your project to save time & ressources.