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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Cell Sourcing - Cell Culture Technologies

Human Islets for Research – Which factors affect their quality?

19/05/2017 by Jean-François Têtu, PhD No Comments
Human Pancreatic Islets - Prodo Laboratories

The islets of Langerhans are the regions of the pancreas that contain its endocrine (i.e., hormone-producing) cells. Discovered in 1869 by German pathological anatomist Paul Langerhans, the islets of Langerhans constitute approximately 1% to 2% of the mass of the pancreas. There are about one million islets distributed throughout the pancreas of a healthy adult human. Each is separated from the surrounding pancreatic tissue by a thin fibrous connective tissue capsule. The islets of Langerhans contain beta cells, which secrete insulin, and play a significant role in diabetes.

Islets are widely used for transplantation to restore beta cell function from diabetes, offering an alternative to a complete pancreas transplantation or an artificial pancreas. Because the beta cells in the islets of Langerhans are selectively destroyed by an autoimmune process in type 1 diabetes, islet transplantation is a means of restoring physiological beta cell function in patients with type 1 diabetes.

Human Islets for Research (HIR)® are primary human islets processed from organ donor pancreases that have been approved for research but not for clinical transplantation of either the  pancreas or the isolated islets. HIR® are obtained in a proprietary process of pancreas digestion and islet purification that results in uniformly high quality HIR® for delivery to diabetes  investigators. Quality Control (QC) testing is routinely performed prior to release to assure uniform quality and function of these islets available for research.

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News

New Human Liver Lysosomes: “Our experiments went fantastically well!”

21/11/2016 by Jean-François Têtu, PhD No Comments

Hearing about results from other researchers is always interesting – we’d like to share a testimonial from our first customer using Human Liver Lysosomes. You can get an idea of how these performed in their experiments.

“Our experiments went fantastically well – we see some potential in the material as a tool to generate metabolites of interest in higher yields than the typical systems. See attached a snapshot of one experiment where we incubated a X compound in development with Hepatocytes, Microsomes and the Lysosomes you provided us with. With Lysosomes we were able to generate a metabolite (M6) with significantly higher yields and this is great because it may be a useful tool to allow full characterization of metabolites”

lysosomes-testimonials

Learn more about Human Liver Lysosomes here: Opening a new era in catabolism models

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Supplying Discovery Tools

Researchers explain why they chose Stembeads FGF2

02/11/2016 by Jean-François Têtu, PhD No Comments

StemBeads® FGF2 is a revolutionary growth factor supplement that offers a more efficient way to grow FGF2 dependent stem cell cultures.
See Stembeads in actionThis supplement delivers a steady release of growth factor into your media of choice creating a more stable environment allowing for:

  • Reduction of media changes by 67%
  • Better culture quality through reduction of spontaneous differentiation
  • No change of culture conditions – use your favourite media

I hear you thinking “Well, that’s just more marketing promises… “. Well, it isn’t, it’s real life!

Just read on and see some of the feedback from researchers…

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Headlines, Stem Cells, Supplying Discovery Tools

All-in-one system for iPS and hES gene editing

10/08/2016 by Jean-François Têtu, PhD No Comments

Today, I’d like to invite you to take a look at a highly efficient and useful kit, which brings together all the required components you need in a complete system for culturing and transfecting human pluripotent stem cells for gene editing.

The PluriQ™ G9™ Gene Editing System includes the G9™ Maintenance Medium and G9™ VTN Recombinant (vitronectin) plate coating for culturing human induced pluripotent (iPS) or embryonic stem (hES) cells in a manner that maximizes transfection by the included EditPro™ Stem Transfection Reagent to transfect genome editing constructs.

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