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Research areas
    ADME-Tox
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tebu-bio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Supplying Discovery Tools

Cell signalling – Discover G-LISA to study Small GTPases

21/06/2018 by Frédéric Samazan No Comments

As is already known, multiple families of small GTPases (Ras, Arf and Rho families) make up the Ras cell signalling - GTPase molecular cycleGTPase superfamily. Due to their role as molecular switches in cell signalling (active GTP-bound state vs inactive GDP-bound states) and in many other cellular responses (cytoskeletal reorganization, regulation of transcription, apoptosis…), these small GTPases are the subject of intense investigation to try to understand the mechanisms that regulate activation and inactivation of this proteins.

In this post, I invite you to discover a revolutionary way to study these cell signalling events by quantifying the level of active small GTPases in your experimental model.

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Supplying Discovery Tools

HDACs: Active drug targets for Immunotherapy treatment

13/06/2018 by Frédéric Samazan No Comments

For many pathologies such as cancer or neurological disorders, it has been found that Histone Deacetylase (HDAC) activity is disrupted, making them promising targets for drug development. Scientists need access to a broade range of products ( Active Enzyme, inhibitors/activators, Biochemical screening assays…), to simplify their research and identification of HDAC inhibitors.

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Supplying Discovery Tools

Live Cell Imaging – Watch SiR-Tubulin stained Human Osteosarcoma cells in action

04/06/2018 by Frédéric Samazan No Comments

As you may already know, Spirochrome have developed a broad range of Live Cell Imaging probes for the staining of DNA, Lysosome, F-Actin and Microtubules.

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Supplying Discovery Tools

New: QuicGSH3.0 – a fluorescent probe to quantify intracellular glutathione

25/05/2018 by Frédéric Samazan No Comments

Glutathione (GSH) is a tri-peptide (Glutamic acid, Cystein and Glycine) present in cells, showing an antioxidant effect allowing the reduction and the removal of Reactive Oxygen Species (ROS) and Peroxide from the cell. The new QuicGSHS3.0 probe from Goryo Chemicals will allow you to easily quantify intracellular concentration of GSH by Fluorescent Live cell Imaging.

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