Even if RNA-based therapeutics have been under development for over 30 years, it was the COVID-19 pandemic that brought them into the limelight, with the rapid development of mRNA-based vaccines against the SARS-Cov2 virus by Moderna and BioNTech/Pfizer. And lipid Nanoparticles (LNPs), used to efficiently deliver mRNA, are key players of this technology.

With the great success of the SIR-probes for efficient labeling of the cell Cytoskeleton, DNA and Lysosome, Spirochrome have just launched a series of 10 new live cell fluorescent tools : The SPY^TM probes.

Developed by Epicypher and available in Europe through tebu-bio, CUTANA CUT&RUN and its sister technology CUT&TAG are quickly becoming the preferred approaches for Chromatin Mapping experiments over the classical method ChiP-Seq. To supplement these advances, EpiCypher is also leading the way for the validation of highly specific antibodies to histone PTMs for chromatin profiling assays. Let’s see how these new antibodies are validated.

Despite its importance in the regulation of many cellular processes, membrane tension is still complicated to measure. And despite valuable insights, the techniques currently available remain complex and present technical limitations. To overcome these drawbacks, Spirochrome have developed Flipper-TR, the first probes for fluorescence microscopy in the field of mechanobiology, that specifically targets the plasma membrane of cells and reports membrane tension through changes in its fluorescence lifetime.