The CRISPR (Clustered, Regularly Interspaced, Short Palindromic Repeats)-Cas (CRISPR-associated) (CRISPR-Cas) system has become trendy as it is suitable for numerous applications such as gene knockouts, genome-engineering, to name but a few. In a recent Technical Bulletin, Ed Davis describes the mechanism of CRISPR-Cas for genome editing and how the recent experimental improvements improve CRISPR-Cas9 specificity while reducing off-target effects.

Access to neural cellular models for in vitro Neuroscience research enters into a new era.

XCell Science, experts in cellular and genome engineering, provide genetically modified cellular models differentiated from Human induced Pluripotent Stem Cell (iPSC) lines. tebu-bio bring its scientific and logistics skills to deliver in Europe these high-quality and characterized neural cell derivatives for R&D, drug discovery, toxicology and regenerative medicine approaches.

Unlimited sources of biologically relevant functional neural cells

Proprietary high-efficiency protocols allow the directed differentiation of these iPS lines into a variety of functional neural cells, such as:

• Neural Stem Cells (NSC),
• Neurons,
• Dopaminergic neurons,
• Astrocytes.

Disease-specific knock-out isogenic neural cell lines

tebu-bio’s experts are pleased to introduce a collection of isogenic knock-out iPSC lines mimicking genetic defects identified in CNS disorders (Parkinson’s and Alzheimer’s diseases, Autism, Schizophrenia and Amyotrophic Lateral Sclerosis (ALS)):

• BDNF-/-: Homozygous knockout of the BDNF gene,
  

  Expression of TH in Ready-to-use XCell DOPA cells prolonged cultured in DOPA medium.

• APOE-/-: Homozygous knockout of the APOE gene,
• DISC1-/-: Homozygous knockout of the DISC1 gene,
• CNTNAP2-/-: Homozygous knockout of the CNTNAP2 gene,
• SOD1-/-: Homozygous knockout of the SOD1 gene,
• Park2-/-: Homozygous knockout of the Park2 gene,
• Park7-/-: Homozygous knockout of the Park7 gene.

Want to know more about these unlimited iPSC-derived neural cellular models ?

XCell Science by tebu-bio

Be among the first to receive the XCell Science launch pack by tebu-bio to optimise your in vitro CNS-specific cellular models.

Sign up now!

iPSC-derived Neural cells characterization – XCell Science by tebu-bio

Related posts regarding CNS and Stem cell studies:

• 3 unique Amyloid Beta peptide (Aß) research tools to boost Alzheimer’s Disease research
• 5 reasons to prefer the MOAB-2 antibody in Alzheimer‘s Disease research
• How is Amylo-Glo a brighter, longer lasting and higher definition Amyloid plaque marker?
• Return of SIRT1 deacetylase – Why is SIRT1 so attractive in Drug discovery and Stem cell research?
• 3 fluorogenic substrates for analyzing undifferentiated iPS and Stem cells
• Study how miRNAs regulate Stem cell homeostasis and differentiation

Celastrol is a biologically active substance initially described in the traditional Chinese medicine. Celastrol (or (9ß,13α,14ß,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid – CAS# 34157-83-0) is now known to be as a potent anti-oxidant and anti-inflammatory small molecule.

Collagen is a structural protein expressed in mammalian tissues (ex. skin, muscles, tendons, ligaments, cartilages, blood vessels…).  Together with Elastin and Keratin, Collagen fibres give connective properties to mammalial tissues ensuring their physiological form but also firmness, strength and flexibility. Needless to say, Collagen is trendy… a simple search in Google using the term “Collagen” clearly shows the economical dimension of this protein in well-being.