Immune checkpoint molecules play an important role in T cell functionality after TCR/MHC signalling. Blockade of two B7/CD28 family checkpoint molecules, CTLA-4 and PD-1, have already demonstrated excellent efficacy in increasing T cell responses to a variety of tumours. Identification of novel target and new checkpoint blockade remains a key element in Drug Discovery (See “Drug discovery: Immunotherapy checkpoint research for new Cancer treatments“). In this post, let’s take a look at the “Quantibody® Human Immune Checkpoint Molecule Array 1” for the detection of 10 Human Immune Checkpoint biomarkers.
VitroGel™ 3D (TheWell Bioscience) is an animal origin-free hydrogel system closely mimicking the natural extracellular matrix (ECM) environment. Cells grown in this 3D hydrogel possess morphologies and cellular behaviours close to their natural state making it ideal for 3D cell culture.
cellphy – study the human body in a petri dish
Therefore, VitroGel™ 3D fits perfectly with our “cellphy” offer, providing life scientists with reagents and laboratory services mimicking the physiological environment of the Human body in vitro, for more physiologically relevant experimental data.
You can choose between two:
- VitroGel™ 3D (cat. nr TWG001): an animal origin-free hydrogel system mimicking the natural ECM, ideal option for floating cell lines.
- VitroGel™ 3D-RGD (cat. nr TWG002): RGD peptide modified hydrogel of VitroGel 3D promoting cell attachment and cell-matrix interactions for 3D-culture and 2D-coating (invasion/migration, chemiotaxis…). Best solution for adhesion cell lines.
Released by the kidneys, Renin is an enzyme which belongs to the Renin-Angiotensin system (RAS) and is involved in blood pressure homeostasis.
In healthcare, Renin assay blood tests can be performed to find the cause of high blood pressure (hypertension). When tested alongside with Aldosterone measurements, one can obtain a complete understanding of an individual’s hormone balance.
Aldosterone Regulatory Hormone Signalling pathway. Souce Arbor Assay
In preclinical and fundamental research, a Renin ELISA test therefore becomes of interest to monitor this biomarker in various disease states particularly when analyzed together with other biomarkers like Aldosterone and Cortisol. Different disorders can then be differentiated such as Primary and Secondary Hyperaldosteronism, Cushing syndrome, and Addison’s disease (adrenal insufficiency)…
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