Following our¬ post¬ on tumour microenvironment and glioblastoma, we will focus today on ameloblastomas.
Ameloblastomas are benign tumours that occur in the jawbone, and¬†invade bone. This type of tumour is treated by surgery and can cause various problems, including¬†changes in facial countenance and mastication disorders.
Ameloblastomas have abundant tumor stroma, including fibroblasts and immune cells. Cell-to-cell interactions in ameloblastoma have not been fully investigated yet. A recent publication by Fuchigami et al. ¬†has investigated the soluble factors (i.e. secretome) involved in the formation and progression of ameloblastoma.
Using the Q-plex technology in a human ameloblastoma cell line (AM-3), as well as human fibroblasts (HFF-2) and primary-culture fibroblasts from human ameloblastoma tissues, they analysed the effect of ameloblastoma-associated cell-to-cell communications. Q-plex was used to study the cytokine secretion, namely IL-1alpha, IL-6, IL-8. Fuchigami et al. conclude¬†that ameloblastoma cells and stromal fibroblasts behave interactively via these cytokines to create a tumour microenvironment (TME) that leads to the extension of this type of tumours.
Would you like to know more about the Q-plex technology? We recently organised a¬†webinar on this technology. Contact us if you want to receive a link with the recorded version or the PDF¬†with the presentation!