5 reasons to prefer the MOAB-2 antibody in Alzheimer ‘s Disease research

MOAB-2 in immunohistochemical detection of Aβ and APP in coronal sections of the frontal cortex of 1-month old 5xFAD mice.

The new pan-specific MOAB-2 is a high-titer monoclonal antibody to Aβ residues 1-4. Here are 5 main reasons that will make you choose it for your research on Alzheimer’s Disease research programs!

#1 – MOAB-2 ensures unparalleled staining quality and clear staining

MOAB-2 provides stronger reactivity and greater sensitivity than any other Aβ monoclonals previously available for research.

#2 – MOAB-2 discriminates between APP and true intraneuronal Aβ in all its forms

Aβ accumulates extracellularly as the disease progresses, making MOAB-2 the ideal reagent for studying both intraneuronal Aβ at early stages and extracellular Aβ at later stages seamlessly.

You’ll get accurate data.

#3 – MOAB-2 does not cross react with APP or APP C-terminal fragments

Unlike other monoclonals such as 6E10 and 4G8, MOAB-2 does not cross react with APP or APP C-terminal fragments, which allows you better isolation and localization of Aβ protein from APP.

MOAB-2 in immunohistochemical detection of Aβ and APP in coronal sections of the frontal cortex of 1-month old 5xFAD mice.

Immunohistochemical detection of Aβ and APP in coronal sections of the frontal cortex of 1-month old 5xFAD mice. Sections were co-stained with M-1586-100 or APP antibodies (N-terminus and C-terminus). MOAB-2 staining was punctate and did not co-localize with either APP antibodies. Figure courtesy of Youmans et al (2012).

#4 – MOAB-2 detects pathogenic Aβ42 over Aβ40

In dot blots, MOAB-2 recognizes all forms (unaggregated, oligometric, and fibrillar) of Aβ 42 protein and the unaggregated form of AB40. MOAB-2 is selective for the more neurotoxic Aβ42 compared to Aβ40. In titration tests, MOAB-2 demonstrated 25 fold greater sensitivity of detection for the U-, O- and F-Aβ42 forms than for Aβ40.

This will allow you to work on the localization and function of Aβ42.

#5 – MOAB-2 belongs to the tebu-bio’s “satisfy or refund” Antibody Program

A large number of qualified primary antibodies are available at tebu-bio. They are all 100% guaranteed for their applications. This is also true for the monoclonal MOAB-2 for research teams keen to use this monoclonal for WB, IHC, IHC (P), IP, IF and ELISA in AD and neurobiology studies.

Get your 100-µg MOAB-2 by following this link.

 

 

MOAB-2 Monoclonal in IF

IHC staining of MOAB-2 on 2,4 and 6 month old 5XFAD mouse hippocampal sections showing increasing Aß staining with MOAB-2 (Red); NeuN staining (Green). Photo courtesy of Dr. Mary Jo LaDu and Dr. Leon Tai from the University of Illinois Chicago, Chicago, IL

Written by Philippe Fixe, PhD
Philippe Fixe is a former Marketing Manager at tebu-bio, passionate about innovation and R&D in Life sciences, Biotechnology, Medical research, Drug discovery, and also a keen photographer.