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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
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    • ADME-Tox
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ADME-Tox

DDI studies: New TransiPort cells for OATP1A2 and OATP2B1 transporters

01/06/2018 by Isabelle Nobiron, PhD No Comments

Membrane transporters can have clinically relevant effects on the pharmacokinetics and pharmacodynamics of a drug in various organs and tissues by controlling its absorption, distribution and elimination. Together with metabolizing enzymes, they can drive a drug’s pharmacological action, as well as a drug can modulate transporter expression or activity, hence the importance of evaluating transporter-mediated drug-drug interactions recommended by the FDA guidelines. Genomembrane have developed transiently expressing ready-to-use cells to study FDA approved transporters (TransiPort). I had described this product range and their unique features in a previous post. I would like to introduce in this one 2 newly released cells overexpressing OATP1A2 and OATP2B1 transporters.

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