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Gene Expression - Molecular Biology

Stable Cas9-expressing cell lines

21/06/2017 by Dimitri Szymczak, PhD No Comments

Shen et al (Nature Methods, 2017) explore and identify synthetic interactions among 73 cancer-associated genes. To perform their loss of function screen they combined CAS9-expressing cell lines with a sgRNA library of high titer lentiviral particles. Most of these gene interactions were subsequently validated by drug treatment.

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