Ppc-1 small molecule: a new mitochondria uncoupling agent

Mitochondria and mitochondrial research

Ppc-1 is a novel small molecule derived from cellular slime mould. In this post, I’d like to introduce the characteristics of this compound for your in vitro mitochondrial research.

ppc-1-mitouncoupler-chemical-structure-funakoshi-tebu-bio

Ppc-1 MitoUncoupler chemical structure. Molecular formula: C21H25NO4 and Molecular weight: 355.43. Source: Funakoshi | tebu-bio.

Ppc-1 has been described to enhance oxygen consumption in a dose-dependent manner.  This compounds also acts as a moderate mitochondrial oxidative phosphorylation uncoupler without adverse effects on ATP production with little cytotoxicity.

In 2015, Suzuki et al. hypothesized that this new mitochondrial regulator could be a valuable tool for mitochondrial research and for obesity treatment. Ppc-1 is now commercially available via Funakoshi and is available in Europe via tebu-bio.

Ppc-1, MitoUncoupler

Ppc-1 (cat. nr 194FDV-0011) is a newly isolated molecule from Polysphondylium pseudo-candidum displaying a mild uncoupling activity in Mitochodria and the following effects:

  • Low effect on ATP synthesis or degradation
  • Low active oxygen generation
  • Low cytotoxicity
  • Cell proliferation is inhibited by adding Ppc-1 to culture medium.

For in vitro research programs focusing on mitochondrial research, Ppc-1 MitoUncoupler (cat. nr 194FDV-0011) increases mitochondria’s oxygen consumption without inhibiting ATP synthesis.

  • Chemical name: 3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enyloxy)quinoline-2-carboxylate
  • CAS No.: 1245818-17-0
  • Solubility: Soluble in DMSO
  • Purity: ≧98%

Ppc-1 related information

*Under license from Tohoku University and Fukushima Medical University School of Medicine.

  • Suzuki T. et. al “Weight Loss by Ppc-1, a Novel Small Molecule Mitochondrial Uncoupler Derived from Slime Mold” (2015) PLoS One, DOI:  10.1371/journal.pone.0117088
  • Kikuchi H. et. al “Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities” (2015) Bioorganic & Medicinal Chemistry Vol. 23, Issue 1, pp 66–72. DOI: 10.1016/j.bmc.2014.11.024
  • Kikuchi H. et. al “Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds” (2010) Tetrahedron, Vol. 66, Issue 32, pp 6000-6007. DOI: 10.1016/j.tet.2010.06.029.

 

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Philippe Fixe, PhD
Written by Philippe Fixe, PhD
Philippe Fixe is Marketing Director at tebu-bio, passionate about innovation and R&D in Life sciences, Biotechnology, Medical research, Drug discovery, and also a keen photographer.