Ppc-1 small molecule: a new mitochondria uncoupling agent
Ppc-1 is a novel small molecule derived from cellular slime mould. In this post, I’d like to introduce the characteristics of this compound for your in vitro mitochondrial research.
Ppc-1 has been described to enhance oxygen consumption in a dose-dependent manner. This compounds also acts as a moderate mitochondrial oxidative phosphorylation uncoupler without adverse effects on ATP production with little cytotoxicity.
In 2015, Suzuki et al. hypothesized that this new mitochondrial regulator could be a valuable tool for mitochondrial research and for obesity treatment. Ppc-1 is now commercially available via Funakoshi and is available in Europe via tebu-bio.
Ppc-1 (cat. nr 194FDV-0011) is a newly isolated molecule from Polysphondylium pseudo-candidum displaying a mild uncoupling activity in Mitochodria and the following effects:
- Low effect on ATP synthesis or degradation
- Low active oxygen generation
- Low cytotoxicity
- Cell proliferation is inhibited by adding Ppc-1 to culture medium.
For in vitro research programs focusing on mitochondrial research, Ppc-1 MitoUncoupler (cat. nr 194FDV-0011) increases mitochondria’s oxygen consumption without inhibiting ATP synthesis.
- Chemical name: 3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enyloxy)quinoline-2-carboxylate
- CAS No.: 1245818-17-0
- Solubility: Soluble in DMSO
- Purity: ≧98%
Ppc-1 related information
*Under license from Tohoku University and Fukushima Medical University School of Medicine.
- Suzuki T. et. al “Weight Loss by Ppc-1, a Novel Small Molecule Mitochondrial Uncoupler Derived from Slime Mold” (2015) PLoS One, DOI: 10.1371/journal.pone.0117088
- Kikuchi H. et. al “Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities” (2015) Bioorganic & Medicinal Chemistry Vol. 23, Issue 1, pp 66–72. DOI: 10.1016/j.bmc.2014.11.024
- Kikuchi H. et. al “Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds” (2010) Tetrahedron, Vol. 66, Issue 32, pp 6000-6007. DOI: 10.1016/j.tet.2010.06.029.
Related mitochondrial uncoupling agents and regulators
- FCCP (Focus Biomecules)
- 2,4-dinitrophenol (DNP) (TargetMol)
- Rotenone (TargetMol)
- Antimycin A (BioAustralis Fine Chemicals)
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