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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
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    • ADME-Tox
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Drug Discovery

IL-17A pathway – a key target for immunotherapies

12/05/2016 by Ali El Baya, PhD No Comments
IL 17-pathway-02 - final

Fig 1: Function of IL-17 in diverse processes

Interleukin-17 (IL-17) is a family of 6 closely related cytokines, designated IL-17A-F, that play a central role in mediating inflammation, autoimmunity, and host defense. IL-17 is mainly secreted by a specific subset of T helper cells known as TH17 cells (for an overview see Fig 1). The IL-17 cytokines mediate their biological functions via surface receptors on target cells. IL-17A binds to IL-17 receptor A (IL-17RA), which stimulates the production of other pro-inflammatory cytokines including IL-6 and IL-8. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17 signaling is also involved in mucosal immunity and host defense against extracellular bacterial and fungal infections (Staph, Candida, Pneumonia, etc.).

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A new photo sent by one of our Travel Grants winners!

by Elodie Monin No Comments

Emelyne RTGHere is a photo sent by Emelyne who is back from a symposium entitled “Gut Microbiota, Metabolic Disorders and Beyond”  in Newport (Rhode Island).

 

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