You suspect your protein binds to microtubules? That it might stabilize or destabilize these filamentous structures? Then this post is here to help you to find a meaningful assay to validate your assumption.
The Receptor Tyrosine Kinases (RTKs) are an important family of cell-surface receptors transmitting extracellular stimuli (ex. NGF, PDGF, FGF, EGF, Insulin…) into intracellular protein-tyrosine kinase activity, which subsequently induces a signal-transduction cascade. This signal transduction pathway leads to the regulation of cellular proliferation, differentiation, and metabolism, but also to gene expression modulation and Ras activation (a GTPase switch protein).