Endocannabinoid in running exercise

Immunohistochemistry staining of human pituitary gland (frozen sections) with anti-human beta Endorphin (GTX21419)
Immunohistochemistry staining of human pituitary gland (frozen sections) with anti-human beta Endorphin (GTX21419)

IHC staining of frozen sections of human pituitary gland with the anti-human beta Endorphin – Genetex / tebu-bio.

Practicing sport creates sudden pleasant “feelings” (euphoria, anxiolysis, analgesia, euphoria…) also known as the “runner’s high”.
For decades, increased levels of ß-endorphins in the blood were associated to this sport-induced positive perception. Today, German researchers (University Medical Center Hamburg-Eppendorf) reveal that, in mice, the brain’s endocannabinoids (like the lipid-soluble endocannabinoid called anandamide) might also contribute to this well-being mood after running exercise.

This conclusion has recently been published in the PNAS review: Fuss et al. “A runner’s high depends on cannabinoid receptors in mice”(2015) PNAS, vol. 112 no. 42, DOI: 10.1073/pnas.1514996112

Here are some research tools we’ve selected to study the endocannabinoid and endorphine systems in vitro:

Philippe Fixe, PhD
Written by Philippe Fixe, PhD
Philippe Fixe is Marketing Director at tebu-bio, passionate about innovation and R&D in Life sciences, Biotechnology, Medical research, Drug discovery, and also a keen photographer.