For one year now, SiR-Actin and SiR-Tubulin, the second generation of tools to stain actin and tubulin in living cells, have been available on the market – and although it may sound like an overstatement, these stains have changed the world of Live Cell Imaging.
Standard curve from the human ELISA kit. This ELISA kit typically detects down to 30 pg/mL of human p75ECD.
You may remember the ice bucket challenge. And the cause behind it, Amyotrophic lateral sclerosis (ALS) (for a very good editorial on this, have a look here).
ALS or Motor neuron disease (MND) is a disease characterised by progressive, debilitating paralysis from loss of motor neurons in the cerebral cortex, brain stem and spinal cord and is almost always fatal. The average life expectancy following diagnosis is just 36 months with, most often, patients succumbing to the disease because of denervation of muscles involved in respiration. There is only one therapeutic option for patients, a Glutamate antagonist, riluzole, which offers a modest 3–6 month extension in survival.