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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
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    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
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News

STAT3 signaling effects on IL-15 derived dendritic cells

22/09/2015 by Ana Arraztio No Comments
JAK-STAT Pathway

The role of STAT3 signaling in the activity of dendritic cells (DC) has been recently revealed in a publication by Okada et al.

Untitled

ELISA array analysis of cytokine expression profiles of LPS/TNFα-treated IL-4 and IL-15 DCs (table from publication).

Dendritic cells (DCs) are important innate and adaptive immune effectors, and have a key role in antigen presentation and T-cell activation. Different lineages of DCs can be developed from hematopoietic progenitors following cytokine signaling (e.g. IL-15, IL-4), and the various lineages of DCs display distinct morphology, phenotype and functions.

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Drug Discovery

Intracellular Calcium measurement with Fluo-8

by Ali El Baya, PhD 12 Comments

G Protein Coupled Receptors (GPCR) and ion channels are important targets in drug development. Both target classes represent membrane proteins which require convenient and robust cell-based assays for screening campaigns. Usually used as readout of such screenings, intracellular Calcium concentration implies the use of Ca2+ indicators able to meet demanding expectations of researchers engaged in assay development and screenings.

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