The role of STAT3 signaling in the activity of dendritic cells (DC) has been recently revealed in a publication by Okada et al.

ELISA array analysis of cytokine expression profiles of LPS/TNFα-treated IL-4 and IL-15 DCs (table from publication).

Dendritic cells (DCs) are important innate and adaptive immune effectors, and have a key role in antigen presentation and T-cell activation. Different lineages of DCs can be developed from hematopoietic progenitors following cytokine signaling (e.g. IL-15, IL-4), and the various lineages of DCs display distinct morphology, phenotype and functions.

G Protein Coupled Receptors (GPCR) and ion channels are important targets in drug development. Both target classes represent membrane proteins which require convenient and robust cell-based assays for screening campaigns. Usually used as readout of such screenings, intracellular Calcium concentration implies the use of Ca²⁺ indicators able to meet demanding expectations of researchers engaged in assay development and screenings.