How to modulate ion channels
Ion channels play an important role in perception and transmission of pain sensations. Furthermore, dysfunctions of certain ion channels are involved in neuronal disorders, such as epilepsy, Alzheimer’s disease, Parkinson’s disease, schizophrenia, and many others. Mutations in ion channel genes have been linked to a wide varity of diseases like policystic kidney disease, cystic fibrosis, and total colour-blindness, to mention just a few. Thus ion channels are natural candidates for pharma R&D programs.
In my previous post Venomous toxin ion channel modulators, I summarized some of the highly class-specific venomous Toxin ion channel modulators that are available. Today, I invite you to take a look at molecules which specifically block or activate ion channels of different classes. These compounds can be used as reference compounds for inhibitor screening campaigns as well as for characterization studies of ion channels of interest.
Focus Biomolecules have compiled a comprehensive library of tools to modulate sodium, potassium, calcium as well as TRP channels.
To get a complete overview of the modulators available, click on the ion channel of your class of interest:
- Sodium channel modulators
- Potassium channel modulators
- Calcium channel modulators
- Transient receptor potential channels (TRP channels)
- Pan specific ion channel blocker
- PIP2-linked ion channel blocker
If you have questions concerning about these compounds, get in touch – any comments are welcome!