Peroxisome proliferator-activated receptor alpha (PPAR-alpha also known as NR1C1) regulates a myriad of biological processes. It is a key modulator of lipid metabolism.
Vergori, L. et al. have shown in murine models how PPAR-alpha regulates endothelial progenitor cell maturation and myeloid lineage differentiation via a NADPH oxidase-dependent mechanism. (1) All the data described in this publication suggest that PPAR-alpha, in murine models, is a critical regulator of recruitment, homing and maturation of Bone Marrow-derived progenitor cells.