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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
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News

Hello from tebu-bio Travel Grant winner Suvi!

22/05/2015 by Elodie Monin No Comments

Suvi

Here is a photo sent by one of tebu-bio’s Travel Grants Winners in February!

She is just back from the 13th Cancer Immunotherapy Meeting in Mainz, Germany.

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Supplying Discovery Tools

Live cell imaging in action: Killer T-cells hunt their target

by Philippe Fixe, PhD No Comments
Killer T Cell - The Cancer Assasin May 2015, University of Cambridge, NIH OxCam programme - Killer T-Cell Credit: Gillian Griffiths/Jonny Settle

In a recent video posted on “Cambridge University’s YouTube channel”, Professor Gillian Griffiths and co-workers prove how the Life Science Community can benefit from modern and innovative cell imaging technologies for understanding cellular activity.

In their recent study (1) and film (2), the research team captured real-time behaviour of Cytotoxic T lymphocytes (CTLs) hunting down, moving and killing cancer cells.

This study clearly illustrates the major breakthrough related to new high spatial and temporal resolution, multi-colour, 3D time-lapse imaging microscopy techniques, which image the entire cell volume and display cellular events at micrometre level.

Watch this fascinating video:

Killer T-Cell Credit: Gillian Griffiths/Jonny Settle . 

Sources:

Professor Gillian Griffiths, Dr Yukako Asano and Akex Ritter – Cambridge Institute for Medical Research – Department of Medicine of the Clinical School (NIH OxCam programme with funding from the Wellcome Trust)

1) Ritter A.T. et al. “Actin depletion initiates events leading to granule secretion at the immunological synapse” (2015) Immunity 42, 864–876. DOI: 10.1016/j.immuni.2015.04.013

2) Body’s ‘serial killers’ captured on film destroying cancer cells – See more at: http://www.cam.ac.uk/research/news

Supplying Discovery Tools

Imaging techniques compatible with Alvetex 3D culture

by Jean-François Têtu, PhD No Comments

As scientists better understand the benefits of growing cells in three dimensions (3D) and routinely adopt 3D culture techniques, methods for visualising cells must also be adapted and optimised.

HaCaT AlvetexThe most common and routinely used technique for tracking two dimensional (2D) cell cultures is light microscopy. Traditional 2D monolayer cultures are highly transparent and within a single optical plane. The minimal light diffraction and diffusion presented by the plastic surface allows the collection of focussed microscopic images. Cells cultured in genuine 3D environments, such as in Alvetex®Scaffold, present some of the same constraints as tissue samples or biopsies, in that simple, live observation of cultures via phase microscopy is not optimal.

There are however, other techniques that can be implemented which will allow the user to monitor culture progress easily and effectively in 3D.

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