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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
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News

PGE2 role in carcinoma chemoresistance via CSC repopulation

11/03/2015 by Philippe Fixe, PhD No Comments
IHC-p analysis with Cytokeratin 14 antibody GTX76600 GeneTex tebu-bio

The involvement of Prostaglandin E2 (PGE2) in cancer development has already been described (see the post “Tumour microenvironment – the dark side of PGE2). Recently, Kurtova et al. confirmed this idea by describing the role of COXII/PGE2 signalling pathway during bladder cancer cytotoxic chemoresistance. (1)

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Antibiotics and microbial metabolites – revisited

by Ali El Baya, PhD No Comments

What are metabolites?

Microorganisms live in a world of chemical signals. They use small molecular weight compounds, known as metabolites, to regulate their own growth and development, to encourage other organisms beneficial to them and suppress organisms that are harmful. To control competitors, microbes produce antibiotics, such as penicillin, streptomycin and erythromycin, antifungals, such as nystatin, amphotericin and cycloheximide, antiprotozoan metabolites including monensin, salinomycin and trichostatins and herbicides like herbicidin and bialophos.  To reduce predation by larger organisms they produce nematocides, such as the avermectins and paraherquamide, and insecticides such as the milbemycins, piericidins and spinosads. To encourage plants and animals they produce growth stimulants and metabolites that inhibit pathogens.

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