In this published work, Novel Three Dimensional Human Endocervix Cultures respond to 28-day hormone treatment (1) , the authors’ goal was to develop a robust three-dimensional (3D) endocervix model that was a reliable representation of the in vivo tissues and to identify the physiological responses to changing levels of steroid hormones during a 28-day time period. Human endocervical cells were grown on polystyrene scaffolds and the morphologic and hormonal responses of cultured cells were assessed in response to fluctuating levels of estradiol (E2) or progesterone (P4).

Neurotrophins are important biomarkers in Neurobiology, including stem cell development to neural lineages. BDNF and NGF are the ones being studied in most cases. However, it has been found that neurotrophins do not act independently. Many publications have described the coordinated actions of 2 or more neurotrophins, especially in development, but also in the adult.