After more than a year of backorder status, EpiCentre Technologies has decided to discontinue all Tobacco Acid Pyrophosphatase (TAP) products and kits containing them. Normally a company discontinuing a product is not major news, but TAP is an important enzyme for RNA biology work and EpiCentre was the only company making it in the world.

Individual-nucleotide resolution UV CrossLinking and ImmunoPrecipitation (iCLIP) enables the identification of protein-RNA interactions. The original CLIP protocol described by Jernej Ule et al. in 2003 (1) has evolved significantly (2, 3), and the current iteration of the iCLIP protocol requires a core set of oligonucleotides and enzymes.