Biologicals are increasingly being used in therapy, helping to cure thousands of patients, or at least improving their quality of life.
Research continues to move forward in this area, as proved by 7 400 citations in 2014 only when using “biologicals” as a search term, or about 200 citations when using “therapeutic mAb”. Many research groups, especially those working on Oncology, continue to investigate on the mechanism of action of biologicals, specially mAbs, as well as on any possible resistances found in non-responsive patients.
For these mechanistic or functional studies, antibody-based techniques such as ELISAs, antibody arrays, flow cytometry, etc. are routinely performed, using samples from patients being treated with therapeutic mAbs.