Research is never easy. That’s why we either like doing it or supporting it.
That said, it’s easier for some researchers than others. If you are working on human, mouse or even rat models, you have quite a wide variety of tools available. Even if you work on zebrafish, at least, you have some validated zebra antibodies, guaranteed to work for your animal model.
What if you are working on other “exotic” animal models? Not by choice, but because they are really the relevant models for your research. Let’s take some examples.