Cytokines and growth factors in Angiogenesis
Angiogenesis is the growth process of new blood vessels from pre-existing one’s. It’s a normal physiological process, observed during embryonic development. But it’s also a pathological process, essentially in the growth of malignant tumors and metastasis development.
Angiogenesis is controlled by different activators and inhibitors made by healthy and tumoral cells.
A large offer of cytokines and growth factors are able to help you in your angiogenesis research.
- Fibroblast Growth Factor-basic: a member of the fibroblast growth factor family (hum FGF-basic, mur FGF-basic, rat FGF-basic)
- Vascular Endothelial Growth Factor: a potent growth & angiogenic cytokine ( hum VEGF 121, hum VEGF 165, mur VEGF 165)
- Epidermal Growth Factor: a growth factor that stmulates cell growth, proliferation and differention by binding to its receptor EGFR (hum EGF, mur EGF, rat EGF)
- Platelet-derived growth factor: one of the numerous growth factors, or proteins that regulate cell growth and division (hum PDGF-BB, mur PDGF-BB)
- Stem beads FGF2: a revolutionary growth factor supplement that offers a more efficient way to grow FGF2 dependent stem cell cultures
- Stem beads EGF: a growth factor that stimulates proliferation of many cell types including stem cells
The growth of angiogenesis is blocked by angiogenesis inhibitors. Endogenous inhibitors are found in the body naturally and are involved in the day-to-day process of regulating blood vessel formation. Here are some anti-Angiogenetic factors.
- Endostatin: an anti-angiogenetic factors that blocks the pro-angiogenic activities of VEGF and FGF-basic
- PF-4: a small cytokine inhibitis angiogenesis (hum PF-4, mur PF-4)
- Interferons (IFNs): theses cytokines are divised into three major types (hum IFN-alpha, hum IFN-ß, hum IFN-gamma, mur IFN-alpha, mur IFN-ß, mur IFN-gamma, rat IFN-Alpha, rat IFN-ß, rat IFN-gamma )
- Interleukins: a group of cytokines that were first seen to be expressed by white blood cells (hum IL-4, mur IL-4, rat IL-4, hum IL-12, mur IL-12)
- Mammary serine protease inhibitor: a non-inhibitory serpin that inhibit angiogenesis and to preferentially promote apoptosis of tumor cells
Any doubt about the best factors for your research?
Finding the tools optimally suited to your needs helps to boost research. Some expert advice in identifying and using the best factors is always welcome!