hypoxia pathway

Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment. Therefore, reliable markers for hypoxia represent both valuable diagnostic markers and potential targets for investigation.

When oxygen becomes limited, prolyl hydroxylase is inhibited which leads to HIF-α accumulation and translocation to the nucleus. HIF-α then dimerizes with HIF-β and interacts with cofactors such as p300/CBP and the Pol II complex to activate the hypoxia-response elements (HRE), which activate transcription of various genes including VEGFA, GLUT1, and CA9.

tebu-bio has selected a panel of primary antibodies related to this pathway.

hypoxia pathway

A selection of 100% guaranteed research antibodies related to the Hypoxia pathway

  • Anti HIF1:  a rabbit polyclonal antibody to HIF1 alpha
  • Anti VHL antibody: a rabbit polyclonal antibody to VHL
  • Anti Heme Oxygenase 1 [N1C3]: a rabbit polyclonal antibody to Heme Oxygenase 1
  • Anti EGLN2: a rabbit polyclonal antibody to EGLN2
  • Anti FIH1: a rabbit monoclonal antibody (clone EPR3659) to FIH1

Looking for a specific intracellular pathway?

We strive to provide you regularly with new and updated pathways to support you in your research. If you are looking for a specific pathway, don’t hesitate to contact us.

[contact-form-7 404 "Not Found"]

 

Avatar
Written by Elodie Monin
Community Manager