Both ROS (Reactive Oxygen Species) and RNS (Reactive Nitrogen Species) on the one hand, and the small G proteins belonging to the Rho family on the other hand, are key regulators in various signal transduction pathways.

More recently it has been suggested that crosstalk between reactive species and Rho GTPases plays a crucial role in some of their physiological functions. Furthermore, these crosstalk events have been linked to pathological processes, e.g. lung injury and cancer.

Our partner Cytoskeleton Inc.  has summarized recent findings in the newsletter Rho GTPases and Reactive Oxygen Species: Crosstalk and Feedback. Let’s take a look at what’s available for research in this area.