Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Numerous cytokines are present within inflammatory sites.

In a previous post, I mentioned that the secretome is becoming a very hot topic in the world of proteome analysis, and even a crucial study subject. Today, I’d like go a step further and shed some light on how to analyse it.

Let’s see what the options are…

Actin filaments are essential for cytoskeleton functions (cell morphology, endocytosis and trafficking, contractility, motility…). In eukaryotic cells, polymerization and depolymerization of actin filaments together with their organization in higher magnitude actin-based superstructures and their complex dynamic properties are regulated by Actin-Binding Proteins (ABPs). Here, let’s review the ABPs recently released for cytoskeleton molecular modeling studies.