The study of neurodegenerative diseases has produced a number of interesting lead compounds but very few that become approved drugs. Over the years High Throughput Screening (HTS) has been used to discover new information on cellular processes in normal and diseased states. Rodent neurons are widely used in these neuronal screening assays but if human cells could be used they would provide an improved model system to study disease biology and be more clinically relevant. Human Induced Pluripotent Stem Cells are becoming a promising option for researchers creating in vitro models for the study of neurodegenerative diseases.