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3 monoclonals to discriminate free Ubiquitin from linear and polyubiquitin chains

15/05/2014 by Philippe Fixe, PhD No Comments
Anti-Ub monoclonals

Ubiquitin (Ub) is an 8 kDa  highly conserved polypeptide, commonly expressed in eukaryotic cells. Ub is added to lysine residues of the target proteins. This post-translational modification (known as ubiquitination) is made through the sequential action of 3 enzymes (E1 Ub activating enzyme, E2 conjugating enzyme and E3 ligase).

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