5 reasons to prefer the MOAB-2 antibody in Alzheimer ‘s Disease research

MOAB-2 in immunohistochemical detection of Aβ and APP in coronal sections of the frontal cortex of 1-month old 5xFAD mice.

The new pan-specific MOAB-2 is a high-titer monoclonal antibody to Aβ residues 1-4. Here are 5 main reasons that will make you choose it for your research on Alzheimer’s Disease research programs!

#1 – MOAB-2 ensures unparalleled staining quality and clear staining

MOAB-2 provides stronger reactivity and greater sensitivity than any other Aβ monoclonals previously available for research.

#2 – MOAB-2 discriminates between APP and true intraneuronal Aβ in all its forms

Aβ accumulates extracellularly as the disease progresses, making MOAB-2 the ideal reagent for studying both intraneuronal Aβ at early stages and extracellular Aβ at later stages seamlessly.

You’ll get accurate data.

#3 – MOAB-2 does not cross react with APP or APP C-terminal fragments

Unlike other monoclonals such as 6E10 and 4G8, MOAB-2 does not cross react with APP or APP C-terminal fragments, which allows you better isolation and localization of Aβ protein from APP.

MOAB-2 in immunohistochemical detection of Aβ and APP in coronal sections of the frontal cortex of 1-month old 5xFAD mice.

Immunohistochemical detection of Aβ and APP in coronal sections of the frontal cortex of 1-month old 5xFAD mice. Sections were co-stained with M-1586-100 or APP antibodies (N-terminus and C-terminus). MOAB-2 staining was punctate and did not co-localize with either APP antibodies. Figure courtesy of Youmans et al (2012).

#4 – MOAB-2 detects pathogenic Aβ42 over Aβ40

In dot blots, MOAB-2 recognizes all forms (unaggregated, oligometric, and fibrillar) of Aβ 42 protein and the unaggregated form of AB40. MOAB-2 is selective for the more neurotoxic Aβ42 compared to Aβ40. In titration tests, MOAB-2 demonstrated 25 fold greater sensitivity of detection for the U-, O- and F-Aβ42 forms than for Aβ40.

This will allow you to work on the localization and function of Aβ42.

#5 – MOAB-2 belongs to the tebu-bio’s “satisfy or refund” Antibody Program

A large number of qualified primary antibodies are available at tebu-bio. They are all 100% guaranteed for their applications. This is also true for the monoclonal MOAB-2 for research teams keen to use this monoclonal for WB, IHC, IHC (P), IP, IF and ELISA in AD and neurobiology studies.

Get your 100-µg MOAB-2 by following this link.

 

 

MOAB-2 Monoclonal in IF

IHC staining of MOAB-2 on 2,4 and 6 month old 5XFAD mouse hippocampal sections showing increasing Aß staining with MOAB-2 (Red); NeuN staining (Green). Photo courtesy of Dr. Mary Jo LaDu and Dr. Leon Tai from the University of Illinois Chicago, Chicago, IL

Philippe Fixe, PhD
Written by Philippe Fixe, PhD
Philippe Fixe is Marketing Director at tebu-bio, passionate about innovation and R&D in Life sciences, Biotechnology, Medical research, Drug discovery, and also a keen photographer.