SIRT1 is a NAD dependent class III Histone Deacetylase (HDAC). The tumor suppressor p53 is not the unique SIRT1 substrate. SIRT1 also deacetylates various key protein targets (PTEN, FOX, HIF-1, XPA, SMAD7 …) involved in the regulation of cellular survival, proliferation and angiogenesis.
SIRT1 – an attractive druggable target in oncology
SIRT1 has rapidly been considered a valuable druggable target because of its implication in p53-dependent apoptosis in response to cellular stress and DNA damage. This enthusiasm was even more enhanced in 2011 when certain studies suggested that a natural dietary polyphenolic compound (Resveratrol) could promote healthy ageing and increase mouse and yeast life span through activation of sirtuins. (1)
Today, SIRT1 returns to the front of the stage with its possible involvement in cellular reprogramming and pluripotency.