Focus on 6 cytokine growth factors for cell culture!

Growth Factors & cytokines

Cytokines and growth factors are signaling molecules that control the activities of cells through intercellular communication. Numerous families of diverse molecules are categorized as cytokines and/or growth factors.

Which are the 6 most popular products?

The factors mentioned below mainly serve as primary components in cell/tissue culture, whereas e.g. PDGFs rather serve as secondary components .

  • Epidermal Growth Factor (EGF)EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells
    • main use in: primary cells, established cell lines (e.g. HeLa, HEK, CHO), Adult stem cells
    • some products: hum EGF, mur EGF, rat EGF
  • Fibroblast Derived Growth Factor-2 (= basic FGF, FGF-basic, FGF-2): Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation
    • main use in: primary cells, established cell lines (e.g. HeLa, HEK, CHO), Adult stem cells,
      Human Embryonic stem cells, Endothelial cells
    • some products: hum FGF-basic, mur FGF-basic, rat FGF-basic
  • Leukemia Inhibitory Factor (LIF): LIF is a pleiotrophic factor produced by multiple cell types including T cells, myelomoncytic lineages, fibroblasts, liver, heart and melanoma.
    • main use in: primary cells, Mouse Embryonic stem cells
    • some products: hum LIF, mur LIF
  • Transforming Growth Factor ß1 (TGF-ß1):  TGF are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix-
    • main use in: primary cells, bone related cells
    • some products: TGF-ß1
  •  Vascular Endothelial Growth Factor (VEGF): VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability
  • Insulin-like Growth Factor 1 (IGF-1): The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro
    • main use in: primary cells; established cell lines (e.g. HeLa, HEK, CHO)
    • some products:  hum IGF-1, mur IGF-1

And which are the cytokines you use the  most?

Contact your local tebu-bio representatives to find the tools suited to your needs.

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Written by Elodie Monin
Community Manager