The LIM-Only Protein FHL2 Reduces Vascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells by Karakula K. et al.
In this study, the authors investigated the modulatory effects of LIM-only protein FHL2/DRA/SLIM3 in phenotypic changes of Smooth Muscles Cells (SMC) in SMC-rich lesion formation.
They have found that FHL2 regulates SMC’s functions during vascular proliferative diseases by modulating Cyclin D1 expression via ERK 1/2 signaling pathway.
Congratulations to the authors, who turned to tebu-bio’s range of products when selecting their growth factors to culture aortic SMC for in vitro scratch-wound and migration assays.
Want to know more?
Source: Karakula K. et al. “The LIM-Only Protein FHL2 Reduces Vascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells” (2014) 9(4): e94931. doi:10.1371/journal.pone.0094931
Related research products:
- A complete offer of active Cytokines and Growth factors and Chemokines PeproTEch including recombinant Mouse PDGF-BB.
- A characterized source of primary Smooth Muscle Cells (SMC) from Human, Mouse, Rat, Bovine origin.
- FHL2 research reagents (from primary antibodies to siRNA, expression vectors and, Gene Reporter Assays, miRNA…).
- Transwell-free in vitro ORIS migration assays.
Oris Cell Migration Assay Video