In this study, the authors investigated the effect of exogenous tissue Plasminogen Activator (tPA) administration on brain levels of pro- and mature Brain-Derived Neurotrophic Factor (BDNF) in rats.
They have shown that t-PA induced a rise in mature BDNF expression and subsequent TrkB receptor activation probably via the N-Methyl-D-Aspartate (NMDA)-Receptors activation rather than through increase in plasmin activity.
Congratulations to the authors, who turned to tebu-bio’s range of products when selecting their discovery tools to measure Plasmin and t-PA activities with Fluorescent Activity Assays (SensoLyte Rh 110 Plasmin and SensoLyte AMC t-PA respectively).
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Source: Rodier M. et al. “Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?” (2014) PLoS ONE 9(3): e92416. doi:10.1371/journal.pone.0092416