HepatoSure® is a pool of human hepatocytes designed to facilitate your DMPK applications with a consistent hepatocyte product over time (years). HepatoSure® is best suited for both discovery and development of ADME-Tox study assays where generation and comparison of data is required. Let’s take a closer look, and you might like to benefit from our […]
Latest Articles
Innovative CleanTag technology provides clean and low input small RNA-seq library
Exploring small RNA transcriptome, a key challenge Small RNA are involved in numerous biological process and linked to a wide range of conditions. For example miRNA can be used for detection of cancers from blood samples and are used for cancer classification. They are involved in the regulation of the messenger RNA translation. Small RNA […]
Biomolecule conjugation – how to biotinylate with reproducible results?
Biomolecule conjugation is critical to many applications such as bead-based assays, ELISA and chromatography by affinity. Unfortunately the classical methods are known to be tedious and with low efficiency. Trilink Biotechnologies has come this year with the solution, an innovative chromophore-linker-based conjugation chemistry called ChromaLink.
CleanCap technology – the new era for mRNA capping has come
Capping is a required protection in 5′ of the mRNA that is necessary for biological activity and stability into the cells. There are already several methods of capping using mCap, ARCA or enzymatic methods. Unfortunately, they are limited in efficiency (such as mCap and ARCA), and can be costly (such as the enzymatic methods). Trilink […]
Simple and effective CRISPR CAS9 gene editing for primary cells
Vector-free CRISPR-CAS9 gene editing to accelerate therapeutic applications A few years ago, Ayal Hendel et al (doi:10.1038/nbt.3290) published results revealing that chemical alterations to sgRNA enhance gene editing in primary cells. To demonstrate this, Matthew H Porteus’s team chose the targeted genes CCR5, HBB and IL2RG respectively involved in anti-HIV clinical trials, cell anaemia and […]
Six new reporter cell lines for Immune checkpoint drug discovery
PD-1:PD:-L1 immune checkpoint pathway targeting immunotherapies have shown great potential for many cancer patients. Recently, The FDA has granted accelerated approval to the immunotherapy drug pembrolizumab (Keytruda® – humanized monoclonal IgG4 antibody against human cell surface receptor PD-1) for use in some patients with advanced gastric stomach cancer (see NIH-NCI news). However, response to these treatments […]
Breast Cancer – Popular validated primary antibodies for research and biomarker discovery
Use of validated antibodies is primordial for Breast Cancer research and related biomarker discovery. Here, we’ll review the main biomarkers involved in this disease and introduce the most popular validated primary antibodies used by our clients.
iPS and Stem cell culture – new high performance xeno-free expansion medium
In collaboration with our partner Ajinomoto, recognised amino-acid experts, we are launching in Europe a new Xeno-free, defined medium for Human Embryonic Stem cells and induced Pluripotent Stem cell (iPS) culture. The new StemFit® Basic02 is a high performance single expansion medium for Stem cell and iPS cell weekend free cell culture.
3 new types of Gastrointestinal (GI) Epithelial primary cells
Gastrointestinal (GI) primary cells represent a powerful approach for the in vitro study of the physiopathology of this unique tissue. Researchers have now identify intimate interactions between GI cells and its microbia with neurological disorders pointing out the need to access highly characterized sources of GI primary cells to design reliable and more physiologically relevant in vitro […]
Live Cell Imaging – Monitor your cellular events by Fluorescent Microscopy
Live Cell Imaging has transformed the way biologists study cellular functions and processes. The observation of dynamic changes provides more insight into the processes happening in a cell, as compared to imaging studies of fixed cells. Goryo Chemical have developed a broad range of innovative Live Cell Imaging fluorescent probes for various applications. Let’s take […]
Obtain clear Western Blot and Immunoprecipitation results
Generating high-quality Immunoprecipitation & Western Blot (IP & WB) data has never been easier. See how you can easily achieve this in our Tips & Tricks section to get clean WB-IP.