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50mg EUR 43
43€


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Erlotinib

Product name
Erlotinib
Catalog number
T0373-50mg (50mg)
Description
Erlotinib hydrochloride (trade name Tarceva, Genentech/OSIP, originally coded as OSI-774) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Similar to gefitinib, erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. Erlotinib has recently been shown to be a potent inhibitor of JAK2V617F activity. JAK2V617F is a mutant of tyrosine kinase JAK2, is found in most patients with polycythemia vera (PV) and a substantial proportion of patients with idiopathic myelofibrosis or essential thrombocythemia. The study suggests that erlotinib may be used for treatment of JAK2V617F-positive PV and other myeloproliferative disorders. -EGFR antagonist 
Source
Target Mol
Product category
Molecules
Product sub category
Inhibitors & Activators
Biological activity
 
Pathway
Tyrosine Kinase/Adaptors
CAS number
183321-74-6
Shipment info
Cool Pack
Nacres Codification
NA.28

Protocol

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