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50ul EUR 306
306€


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Anti BRCA1

Product name
Anti BRCA1
Catalog number
BS6423-50ul (50ul)
Description
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. 1mg/ml in PBSwith0.1%SodiumAzide,50%Glycerol.BRCA1 pAb detects endogenous levels of BRCA1 protein.The antibody was a 
Source
Bioworld technology
Product category
Antibodies
Product sub category
Primary Antibodies
Target species
Human, Mouse, Rat
Target's name
Breast cancer type 1 susceptibility protein, RING finger protein 53, BRCA1, RNF53
Host
Rabbit
Clonality
Polyclonal
Application
WB, IHC, IF
Shipment info
Cool Pack
Nacres Codification
NA.41

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