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50ul EUR 247
247€
100ul EUR 439
439€


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KIT (phospho-Y936) polyclonal antibody

Product name
KIT (phospho-Y936) polyclonal antibody
Catalog number
BS64218-50ul (50ul)
BS64218-100ul (100ul)
Description
Alternative Name: Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD117; KIT; SCFR
c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3/flk-2 receptors. It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells. Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization/oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLC?, the p85 subunit of PI3 kinase, SHP2, and CrkL. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, and mutations that constitutively activate c-Kit can lead to 
Source
Bioworld technology
Product category
Antibodies
Product sub category
Primary Antibodies
Cross-reactivity
Human
Host
Rabbit
Application
WB
Biological activity
 
Shipment info
Cool Pack
Nacres Codification
NA.41

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Protocol

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