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2mg(10mm) EUR 325
325€


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Recent History

LDN-193189 in Solution

Product name
LDN-193189 in Solution
Catalog number
04-0074-02 (2mg(10mm))
Description
LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively)1. LDN-193189 was derived from structure-activity relationship studies of Dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK71. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms4,5. LDN-193189 has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva1. 
Source
Stemgent
Product category
Molecules
Product sub category
Chemicals
Biological activity
 
Shipment info
Cool Pack
Nacres Codification
NA.28

Download the datasheet

Download the PDF datasheet

Protocol

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