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Recent History

Valproic Acid

Product name
Valproic Acid
Catalog number
04-0007 (5g)
Stemolecule Valproic Acid (VPA) is a cell-permeable, small molecule that has been shown to affect several pathways. VPA is a histone deacetylase (HDAC) inhibitor which improves reprogramming efficiency by at least 100 fold1. VPA also has been found to affect both the Extracellular Signal-Regulated Kinase (ERK), Protein Kinase C (PKC), and the Wnt/Beta-Catenin pathways. VPA has been reported to regulate the differentiation and proliferation of various cells, including mesenchymal and hematopoietic stem cells, neuroblastoma cells, primary neurons and neural progenitor cells (NPCs)2. In the case of hepatic differentiation of mouse embryonic stem cells, Valproic Acid in combination with cytokines differentiate cells into a uniform and homogeneous cell population of hepatic progenitor cells followed by maturation into functional hepatocytes3. 
Product category
Product sub category
Biological activity
Shipment info
Room Temperature
Nacres Codification

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