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5x10ug EUR 165
165€
100ug EUR 198
198€
500ug EUR 578
578€
1mg EUR 985
985€


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Phrixotoxin-2

Product name
Phrixotoxin-2
Catalog number
PHX002-50010 (5x10ug)
PHX002-00100 (100ug)
PHX002-00500 (500ug)
PHX002-01000 (1mg)
Description
AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Arg-Ile-Ile-Asn-Met-NH2-Disulfide bonds:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25-Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Kv1, Kv2 and Kv3 channel subfamilies are insensitive to this toxin. 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
CAS number
221889-63-0
Shipment info
Room Temperature
Nacres Codification
NA.26

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