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5x10ug EUR 132
132€
100ug EUR 149
149€
500ug EUR 429
429€
1mg EUR 605
605€


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Mu-conotoxin GIIIB

Product name
Mu-conotoxin GIIIB
Catalog number
CON020-50100 (5x10ug)
CON020-00100 (100ug)
CON020-00500 (500ug)
CON020-01000 (1mg)
Description
AA sequence: Arg-Asp-Cys3-Cys4-Thr-Hyp-Hyp-Arg-Lys-Cys10-Lys-Asp-Arg-Arg-Cys15-Lys-Hyp-Met-Lys-Cys20-Cys21-Ala-NH2-Disulfide bonds: Cys3-Cys15, Cys4-Cys20 and Cys10-Cys21-u-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. u-conotoxin GIIIB adopts a compact structure consisting of a distorted 310-helix and a small Beta-hairpin. u-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. u-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. u-Conotoxin GIIIB selectively blocks Nav1.4 (u1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM. u-Conotoxi 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
CAS number
140678-12-2
Shipment info
Room Temperature
Nacres Codification
NA.26

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