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5x10ug EUR 176
176€
100ug EUR 198
198€
500ug EUR 578
578€
1000ug EUR 985
985€


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AmmTx3

Product name
AmmTx3
Catalog number
AMX001-50010 (5x10ug)
AMX001-00100 (100ug)
AMX001-00500 (500ug)
AMX001-01000 (1000ug)
Description
AmmTx3 is a blocker of A-type potassium channels.-AmmTx3 has been originally isolated from the venom of the scorpion Androctonus mauretanicus and is now offered by Smartox in its synthetic version. AmmTx3 binds on its target A-type potassium channel with an affinity of 66 pM in rat brain synaptosomes (Kv4 channels). As such, AmmTx3 should represent an excellent tool to study action potential firing frequency, spike initiation and waveform in excitable cells. AmmTx3 was indeed found to block A-type potassium currents from cerebellum granular cells and from striatum neurons but with IC50 values of 130 nM. AmmTx3 appears to be a pore blocker of Kv4.2 and Kv4.3 and seems to require the expression of the Kv4 associated protein DPP6. It should also contribute to our understanding of learning, memory and behavior. AmmTx3 shares very high sequence homology with two other A-type potassium channel blockers, Aa1 from Androctonus australis (94%) and BmTx3 from Buthus martensi (91%), and according 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
Shipment info
Room Temperature
Nacres Codification
NA.26

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