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TinyButStrong Error in field [var.itemIDs...]: the key 'itemIDs' does not exist or is not set in VarRef. (VarRef seems refers to $GLOBALS) This message can be cancelled using parameter 'noerr'.

TinyButStrong Error in field [var.itemIDs...]: the key 'itemIDs' does not exist or is not set in VarRef. (VarRef seems refers to $GLOBALS) This message can be cancelled using parameter 'noerr'.

TinyButStrong Error in field [var.itemIDs...]: the key 'itemIDs' does not exist or is not set in VarRef. (VarRef seems refers to $GLOBALS) This message can be cancelled using parameter 'noerr'.

TinyButStrong Error in field [var.itemIDs...]: the key 'itemIDs' does not exist or is not set in VarRef. (VarRef seems refers to $GLOBALS) This message can be cancelled using parameter 'noerr'.
(Dap22)-ShK 13SHD001-00010 Peptide | tebu-bio
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Recent History

(Dap22)-ShK

Product name
(Dap22)-ShK
Catalog number
Description
Selective blocker of Kv1.3: (Dap22)-ShK (ShK Dap22) peptide is a synthetic derivative of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks voltage-gated Kv1.1, Kv1.3, Kv1.4 and Kv1.6 channels at equal subnanomolar concentrations. In (Dap22)-ShK, lysine22 has been replaced by a diaminopropionic acid (Dap) residue that greatly improves the selectivity of the peptide for the voltage-gated potassium channel Kv1.3 (IC50 around 23 pM) against Kv1.1 (1.8 nM), Kv1.4 (37 nM) and Kv1.6 (10 nM) channels. The high selectivity of (Dap22)-Shk is achieved thanks to the strong binding between the Dap and His404 / Asp386 residues of Kv1.3 channel. (Dap22)-ShK inhibits T cell proliferation induced by anti-CD3 at subnanomolar concentrations.-Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Dap-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OH-Di 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
Shipment info
Room Temperature
Nacres Codification
NA.26

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