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100ug EUR 149
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Hainantoxin III

Product name
Hainantoxin III
Catalog number
13HTX003-00100 (100ug)
13HTX003-00500 (500ug)
13HTX003-01000 (1mg)
Hainantoxin-III is a peptide that has been isolated from the venom of the Chinese bird spider Seleconosmia hainana. Hainantoxin-III specifically blocks mammalian neuronal tetrodotoxin-sensitive voltage-gated sodium channels (VGSCs). Hainantoxin III was found inactive on tetrodotoxin-resistant VGSCs and voltage-gated Ca2 channels (both high and low voltage-activated).-Hainantoxin-III strongly depressed the amplitude of rat DRG tetrodotoxin-sensitive Na currents with an IC50 value of 1.1 nM. Like Hainantoxin-IV, Hainantoxin-III causes a hyperpolarizing shift of about 10 mV in the voltage midpoint of steady-state Na channel inactivation. Similar to Huwentoxin-IV, Hainantoxin-III and -IV do not affect the activation and inactivation kinetics of Na currents. -Hainantoxin-III inhibits Nav1.7 current amplitude without significantly altering the activation and inactivation kinetics. Hainantoxin-III increases the deactivation of the Nav1.7 current after extreme depolarizations. Hainantoxin- 
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Shipment info
Room Temperature
Nacres Codification

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