tebu-bio is a European company specialised in providing innovative reagents and laboratory services in Life Sciences
X

Need an answer now?

Give us a call

Leave a message, we'll get back to you





Move

Product added to your basket !


Continue your visit View your basket
100ug EUR 385
385€
500ug EUR 1155
1155€


Contact us

Recent History

PROTOXIN II Biotin

Product name
PROTOXIN II Biotin
Catalog number
12PTB002-00100 (100ug)
12PTB002-00500 (500ug)
Description
Protoxin II is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). Protoxin II inhibits voltage-gated calcium and sodium channels (site 4). This toxin inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. The toxin potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximately 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. Protoxin II also binds to phospholipids. ProTx-II, a selective inhibitor of Nav1.7 sodium channels,-blocks action potential propagation in nociceptors. 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
Biotin
Shipment info
Room Temperature
Nacres Codification
NA.26

Request the Datasheet

First name
Last name
Email *
Country *:
Company name *
  
* Fields marked with an asterisk are required.



Protocol

To access the protocol, please provide your email address :