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100ug EUR 220
220€
500ug EUR 660
660€
1mg EUR 1045
1045€


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JINGZHAOTOXIN III

Product name
JINGZHAOTOXIN III
Catalog number
12JZH003-00100 (100ug)
12JZH003-00500 (500ug)
12JZH003-01000 (1mg)
Description
Jingzhaotoxin-III (Beta-TRTX-Cj1Alpha) has been isolated initially from the Chinese Tarantula spider Chilobrachys Jingzhao venom. Jingzhaotoxin-III selectively inhibits the voltage-dependent sodium channel Nav1.5 channel with an IC50 value close to 350 nM. It is inactive on Nav1.2, Nav1.4, Nav1.6 and Nav1.7 and should therefore be considered as an interesting research tool to discriminate between sodium channel subtypes. The toxin binds onto receptor site 4 presumably located on DIIS3-S4 linker of Nav1.5 and supposedly blocks Nav1.5 through a different mechanism than ProTx-II and Huwentoxin IV. Beta-TRTX-Cj1Alpha is composed of 36 amino acid residues including 6 cysteines cross-linked according to a C1-C4, C2-C5 and C3-C6 pattern.-Sequence: Asp-Gly-Glu-Cys4-Gly-Gly-Phe-Trp-Trp-Lys-Cys11-Gly-Arg-Gly-Lys-Pro-Pro-Cys18-Cys19-Lys-Gly-Tyr-Ala-Cys24-Ser-Lys-Thr-Trp-Gly-Trp-Cys31-Ala-Val-Glu-Ala-Pro-(Disulfide bonds between Cys4-Cys19, Cys11-Cys24, and Cys18-Cys31) 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
Shipment info
Room Temperature
Nacres Codification
NA.26

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